People

Program Director - Steffany A.L. Bennett, PhD

Steffany A.L. Bennett

Professor
Neural Regeneration Laboratory
Ottawa Institute of Systems Biology
Biochemistry, Microbiology, and Immunology
Faculty of Medicine

 


(613) 562-5800 x8372
sbennet@uottawa.ca

Dr. Bennett is a lipid biochemist, systems biologist, and neurobiologist whose expertise lies in the mechanistic profile of phospholipids in Alzheimer Disease and Parkinson's Disease. She is the Director of the CIHR Training Program in Neurodegenerative Lipidomics, University Research Chair in Neurolipidomics, and the Associate Director Education of the Ottawa Institute of Systems Biology.

Research Interests

Researchers in the Neural Regeneration Laboratory work towards identifying new therapeutic targets that can reduce brain damage or restore brain function following injury. Using a targeted neurolipidomics approach, we are identifying (a) circulating phospholipids and glycolipids at the molecular level that predict disease conversion, (b) how changes in these structural and second messenger lipids signal neurodegeneration, and (c) whether these changes can be targeted to resist neurodegenerative disease in the central nervous system.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A-F

 

Dr. Bennett is currently recruiting. Please click here for details.

John T. Arnason, PhD

John T. Arnason

Professor
Biology

Faculty of Science


(613) 562-5262
john.arnason@uottawa.ca

Dr. Arnason is a ethnopharmacologist and medicinal chemist. He is the Anti-Infectives and Natural Products Group Leader for the Centre for Research in Biopharmaceuticals and Biotechnology and the Director of Undergraduate Biotechnology Program at the University of Ottawa.

Research Interests

Research interests of Dr. Arnason's natural products group lie in ethnopharmacology, medicinal plants, phytochemistry ,and chemical ecology. Current research includes study of traditionally used anxiolytic, antidiabetic, insecticidal, anti-infective, and neuroprotective plants.

Program Curriculum [details]

Biomarker/Drug Discovery; Themes: B,D,E

 

Dr. Arnason is currently recruiting. Please click here for details.

John Baenziger, PhD

John Baenziger

Professor
Biochemistry, Microbiology, and Immunology
Faculty of Medicine

 


(613) 562-5800 x8222
jebaenz@uottawa.ca

Dr. Baenziger is a lipid biochemist studying the structural characterization of integral membrane proteins and lipid interactions using physical methods.

Research Interests

Dr. Baenziger's research focuses on the structural examination of integral membrane receptors altered in Alzheimer Disease, specifically 1) determining how the nicotinic acetylcholine receptor structure changes upon ligand binding and 2) how these changes modulate the formation of lipid microdomains and rafts from both biochemical and structural biology perspectives.

Program Curriculum [details]

Neuroscience/Cell Biology: Themes: C

 

Dr. Baenziger is currently recruiting. Please click here for details.

Kristin Baetz, PhD

Kristin Baetz

Associate Professor
Ottawa Institute of Systems Biology
Biochemistry, Microbiology, and Immunology
Faculty of Medicine

 


(613) 562-5800 x8592
kbaetz@uottawa.ca

Dr. Baetz is a yeast geneticist exploring the molecular and genetic bases for chromosomal instability. She is a member of the Ottawa Institute of Systems Biology, an Assistant Professor in the Department of Biology, Microbiology and Immunology, University of Ottawa, and holds a Canadian Research Chair in Chemical and Functional Genomics.

Research Interests

The Baetz lab seeks to understand how chromatin structure impacts upon chromosomal stability through the use of sophisticated high-throughput robotics based functional genomics. Her laboratory is expert in high-throughput yeast genomic screening and applies these technologies as part of her mentorship in the CIHR Training Program in Neurodegenerative Lipidomics to predict drug mode of action on lipid metabolism and identify signaling targets of pathogenic and protective lipid second messengers.

Program Curriculum [details]

Systems Biology; Themes: B,C,E

 

Dr. Baetz is currently recruiting. Please click here for details.

David Bickel, PhD

David Bickel

Associate Professor
Ottawa Institute of Systems Biology
Biochemistry, Microbiology, and Immunology
Faculty of Medicine

 


(613)562-5800 x8670
dbickel@uottawa.ca

Dr. Bickel is a biostatistician developing new statistical methods to analyze gene, protein, and lipid expression data. His research leverages recent advances in evidential-likelihood and empirical Bayes inference for more reliable interpretation of transcriptomic, proteomic, and lipidomic data.

Research Interests

Dr. Bickel's laboratory focuses on developing new ways to mathematically assess evidence relevant to health care, agricultural, and other applications in the post-genomic era. His team is dedicated to improving statistical methods of weighing evidence, enabling more reliable interpretations of measurements of transcript, protein, or lipid metabolite levels in the cell.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A-F

 

Dr. Bickel is currently recruiting. Please click here for details.

Sandra Black, MD, FRCP

Sandra Black

Professor
Neurology
University of Toronto
Sunnybrook Health Science Centre

 


sandra.black@sunnybrook.ca

Dr. Black is a clinical scientist studying and treating neurological degeneration. She is the Brain Sciences Program Research Director at the Sunnybrook Research Institute, the Brill Chair in Neurology at the University of Toronto/Sunnybrook Health Sciences Centre, and the Interim Scientific Director of the Heart and Stroke Centre for Stroke Recovery.

Research Interests

Research in the Black laboratory focuses on neural degeneration and regeneration with regards to stroke and stroke recovery. Specifically she examines the cognitive brain sequelae regarding all aspects of stroke. Additionally Dr. Black's laboratory looks at differential diagnosis and monitoring of dementia through the use of multiple neuropsychiatric and imaging techniques. These efforts are used to examine the states of dementia associated with conditions such as Alzheimer and Parkinson's Disease.

Program Curriculum [details]

Biomarker/Drug Discovery: Themes: A,D,F

Jean-François Couture, PhD

Jean-Francois Couture

Associate Professor
Ottawa Institute of Systems Biology
Biochemistry, Microbiology, and Immunology
Faculty of Medicine

 


(613)562-5800
jean-francois.couture@uottawa.ca

Dr. Couture holds a Canada Research Chair in Structural Biology and Epigenetics studying lipid-protein and protein-protein interactions in the context of the structural regulation of transcription.

Research Interests

Research in the Couture laboratory focuses on cellular epigenetics. Specifically Dr. Couture uses structural techniques to examine how chromatin (and associated protein) dynamics regulate 1) histone modifying enzymes (HMEs), 2) polypeptide cofactors regulating HME activities and 3) histone deposition.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A-F

 

Dr. Couture is currently recruiting. Please click here for details.

Stephen Fai, PhD

Stephen Fai

Associate Professor
Azrieli School of Architecture and Urbanism
Faculty of Engineering and Design

 


(613) 520-2600 x2867
sfai@cims.carleton.ca

Dr. Fai is an architect and historian. He is the Director of the Carleton Immersive Media Studios and the Acting Chair, Ph.D. Program, Azrieli School of Architecture and Urbanism.

Research Interests

Research interests of Carleton Immersive Media Studio include the representation and creation of architecture, religion and architecture, microhistory, hybrid representation, and ethno-cultural materials and methods of construction (architecture, science, engineering, and biomedical imaging/representation). Architectural technologies, and ethno-cultural explorations are applied to the representation of molecular and cognitive changes in diseased brain. Neurolipidomic researchers at CIMS use state-of-the-art visualization and immersive technologies to facilitate communication within the research community and general public.

Program Curriculum [details]

Systems Biology; Themes: A,F

 

Dr. Fai is currently recruiting. Please click here for details.

Daniel Figeys, PhD

Daniel Figeys

Professor
Ottawa Institute of Systems BIology
Biochemistry, Microbiology, and Immunology
Faculty of Medicine

 


(613)562-5800 x8674
dfigeys@uottawa.ca

Dr. Figeys is a Systems Biologist and Analytical Chemist. He is the Director of the Ottawa institute of Systems Biology, University of Ottawa and a Canada Research Chair in Proteomics and Systems Biology.

Research Interests

Research in the Figeys laboratory focuses on 1) mapping protein-protein and protein-lipid interactions of proteins and lipids relevant to human diseases, 2) validating the roles that some of these proteins and lipids play in human diseases, and 3) developing novel proteomic and lipidomic approaches to study diseases

Program Curriculum [details]

Systems Biology; Themes: A-F

 

Dr. Figeys is currently recruiting. Please click here for details.

Paul Fraser, PhD

Paul Fraser

Professor
Medical Biophysics, Faculty of Medicine
Centre for Research in Neurodegenerative Diseases

 


(416) 978-0101
paul.fraser@utoronto.ca

Dr. Fraser is a neurobiologist. He holds the Diener Chair in Neurodegenerative Diseases and is the Director of the Microscopy Imaging Laboratory in the Centre for Research in Neurodegenerative Disease, University of Toronto.

Research Interests

Research in the Fraser laboratory focuses on the biochemistry and biophysics of amyloid plaques and their relationship to familial and sporadic Alzheimer Disease. A second line of investigation focuses on understanding the biochemistry and structural biology of the presenilin family of proteins. A third line of investigation examines PTEN-induced kinase-1 (PINK1) linked to familial Parkinson’s disease.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A,C

 

Dr. Fraser is currently recruiting. Please click here for details.

Krista Lanctôt, PhD

Krista Lanctot

Professor

Psychiatry and Pharmacology/Toxicology

Faculty of Medicine

 


416-480-6100, ext. 2241
krista.Lanctot@sunnybrook.ca

Dr. Lanctôt is a pharmacologist and neuroscientist. She is a Senior Research Scientist at the Sunnybrook Health Sciences Centre and Professor at the University of Toronto. She is the Executive Director of the Medical Outcomes and Research in Economics Institute.

Research Interests

Neuropsychiatric symptoms are common sequelae of many central nervous system disorders such as dementia, traumatic brain injury and stroke. The goal of the Lanctôt laboratory is to optimize the psychopharmacological management of these neuropsychiatric symptoms.

Program Curriculum [details]

Biomarker/Drug Discovery; Themes: D,E

Claude Messier, PhD

Claude Messier

Professor
School of Psychology
Faculty of Social Sciences

 


613-562-5800 ext. 4562
cmessier@uottawa.ca

Dr. Messier is a behavioural neuroscientist studying impact of metabolic changes in glucose transport and availability on learning and memory in Alzheimer Disease. He is the Director of the Behavioural Neuroscience stream of the Experimental Psychology graduate program at the University of Ottawa.

Research Interests

Research in the Messier laboratory focuses on how glucose modulates memory in the mammalian brain. This research has three main areas of interest 1) Functional changes produced by memory processing using immunocytochemical detection 2) Interaction between glucose metabolism and memory processes in animals and humans 3) Physiology and neuropsychology of memory.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A,E

 

Dr. Messier is currently recruiting. Please click here for details.

David Park, PhD

David Park

Professor
Department of Cellular and Molecular Medicine
Faculty of Medicine

 


(613)562-5800 x8816
dpark@uottawa.ca

Dr. Park is a neuroscientist studying molecular mechanisms of stroke and Parkinson's Disease. He is a Heart and Stroke Career Investigator, the Co-director of the Parkinson's Research Consortium, a member of the scientific board of the Parkinson's Society of Canada, and the Assistant Dean of Medicine, Research and Special Projects.

Research Interests

The Park laboratory focuses on investigating the signaling pathways involved in neuronal cell death. Two specific areas are targeted: 1) examining the signaling molecules that control apoptosis via trophic factor deprivation, 2) Identify the relevant apoptotic regulators in animal models of brain pathology.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A,C

 

Dr. Park is currently recruiting. Please click here for details.

Michael Schlossmacher, MD, FRCP

Michael Schlossmacher

Scientist
Neuroscience, Ottawa Hospital Research Institute
Faculty of Medicine

 


(613)562-5800 x8123
mschlossmacher@ohri.ca

Dr. Schlossmacher is a neurologist and Canada Research Chair in Parkinson's Disease exploring the quantification of alpha-synuclein protein and its lipid modifications for biomarker purposes in Parkinson's Disease. He is a Senior Scientist at the OHRI and holds the Bhargava Research Chair in Neurodegeneration at the Ottawa Hospital.

Research Interests

The Schlossmacher laboratory is pursuing three complementary goals: 1) to contribute to the development of a biomarker for Parkinson disease (PD) 2) to contribute to the understanding of the cause(s) of PD, 3) to explore targets for cause-directed treatment of PD.

Program Curriculum [details]

Biomarker/Drug Discovery; Themes: B,C,D

 

Dr. Schlossmacher is currently recruiting. Please click here for details.

Ruth Slack, PhD

Ruth Slack

Professor
Department of Cellular and Molecular Medicine
Faculty of Medicine

 


(613)562-5800 x8459
rslack@uottawa.ca

Dr. Slack is a neuroscientist studying molecular mechanisms of neurogenesis and neurodegeneration. She is the Assistant Dean of Medicine, Graduate and Postdoctoral Studies.

Research Interests

Dr. Slack's laboratory targets the molecular mechanisms regulating neurogenesis with the intent of optimizing cell replacement therapies following brain injury. Her team is also working on identifying key molecular targets regulating neuronal cell death after injury. This type of research is crucial for the development of effective therapies for the treatment of acute brain injury.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A,C

 

Dr. Slack is currently recruiting. Please click here for details.

Anurag Tandon, PhD

Anurag Tandon

Associate Professor
Neurology, Faculty of Medicine
Centre for Research in Neurodegenerative Diseases

 


(416) 978-8880
a.tandon@utoronto.ca

Dr. Tandon is a neurobiologist and CIHR New Investigator expert in transgenic animal models of Parkinson's Disease.

Research Interests

Research in the Tandon laboratory focuses on Parkinson’s disease (PD), a progressive neurodegenerative disorder that is influenced by genetic and environmental factors. α-Synuclein (α-syn) is a key pathogenetic factor involved in both inherited and sporadic forms of PD, as well as other neurodegenerative diseases. Mutations in the α-synuclein gene cause familial PD. One of the consistent biochemical features of these diseases is a change in α-syn solubility, and his team's work aims to determine how its membrane binding is regulated and with which other proteins it interacts.

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A,C,D

 

Dr. Tandon is currently recruiting. Please click here for details.

John Woulfe, PhD, MD, FRCP

John Woulfe

Clinician and Associate Scientist
Ottawa Hospital Research Institute
Faculty of Medicine

 


(613)562-5800 x8123
jwoulfe@ottawahospital.on.ca

Dr. Woulfe is the Attending Staff Neuropathologist, Department of Laboratory Medicine, Ottawa Hospital, Civic Campus and Associate Scientist at the Ottawa Hospital Research Institute expert in tau pathology, amyloidosis, and Alzheimer Disease pathology.

Research Interests

The Woulfe laboratory is examining the role of neuronal intranuclear inclusions in health and disease, specifically 1) tubulin-immunoreactive intranuclear Inclusions in the human brain and 2) b) ubiquitinated neuronal intranuclear Inclusions in frontotemporal dementia. His team is exploring a novel type of intranuclear inclusion body in the normal human brain to reveal clues to intranuclear inclusion formation in neurodegenerative disease as well as a unique non-tau, non-synuclein related form of frontotemporal dementia present in subgroups of patients.

Program Curriculum [details]

Biomarker/Drug Discovery; Themes: A,C,D

 

Dr. Woulfe is currently recruiting. Please click here for details.

Zemin Yao, PhD

Zemin Yao

Professor and Chair
Biochemistry, Microbiology, and Immunology
Ottawa Institute of Systems BIology
Faculty of Medicine

 


(613)562-5800 x8202
zyao@uottawa.ca

Dr. Yao is a lipid biochemist studying the metabolism of lipids and lipoproteins in disease. He is the Chair of the Department of Biochemistry, Microbiology, and Immunology, University of Ottawa.

Research Interests

Research in the Yao laboratory focuses on the lipid and protein factors that regulate the biosynthesis of low and high density lipoproteins (LDL and HDL) yielding insights into the molecular mechanisms responsible for various diseases, including familial defective apoB (that causes high blood concentration of LDL), familial hypobetalipoproteinemia and familial abetalipoproteinemia (both have abnormally low blood concentration of LDL), and familial combined hyperlipidemia (caused by overproduction of disease-causing lipoproteins).

Program Curriculum [details]

Neuroscience/Cell Biology; Themes: A,C

 

Dr. Yao is currently recruiting. Please click here for details.