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Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration.

 

Highlight by Graham Mazereeuw

 


Up to 50% of coronary artery disease (CAD) patients will experience a depressive episode after a cardiac event, often for prolonged periods of time. Depression in CAD patients is of high clinical importance as it doubles the risk of acute ischemic events and is linked with accelerated cognitive decline and the transition to dementia. Unfortunately, antidepressant pharmacotherapies have only modest effects in CAD patients and novel approaches are limited by a poor understanding of underlying mechanisms. In a novel hypothesis to explain this relationship, we recently proposed that the platelet activating factor (PAF) family of alkylacylglycerophosphocholines (AAGPCs) may be associated with the onset and/or persistence of a depressive episode in CAD patients due to their association with CAD and with proposed mechanisms for depression. Emerging preclinical evidence supports this by indicating that disrupted lipid metabolism may be a converging point for several pathophysiological processes active in both depression and CAD. PAFs and other AAGPCs are remodelled at the cellular membrane in response to multiple extracellular inputs such as inflammatory activity, oxidative stress, and platelet reactivity, all of which are present in depressed CAD patients. PAFs also mediate cerebrovascular pathology and neurodegenerative processes that are commonly observed in patients with prolonged depression. Currently, PAFs represent unexplored potential mechanistic markers of depression in CAD. As such, elucidation of their tole may lead to a better understanding of its underlying mechanisms and the potential identification of novel therapeutic targets.

 

posted 16 Dec 2013
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References:
Original research paper

Mazereeuw G, Herrmann N, Bennett SAL, Swardfager W, Xu H, Valenzuela N, Fai S, Lanctôt KL, (2013) Platelet activating factors in depression and coronary artery disease: a potential biomarker related to inflammatory mechanisms and neurodegeneration. Neurosci Biobeh Rev 37:1611-1621. doi: 10.1016/j.neubiorev.2013.06.010.
Pubmed 23800745

 

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