Desktop application v1.0.0 | August 2026
Download for Mac OS (Apple Silicon) | 1.08 GB Download User Guide Download Sample Files
Desktop application v1.0.0 | August 2026
Download for Mac OS (Apple Silicon) | 1.08 GB Download User Guide Download Sample Files
Desktop application v1.0.0 | August 2026
Download for Mac OS (Apple Silicon) | 1.08 GB Download User Guide Download Sample FilesAfter installation and upon opening iDMS, please go to System Settings → Privacy & Security, scroll to Security, then click Open Anyway to allow the app to launch. This only needs to be done once.
iDMS is an in silico supervised neural network model that learns the field asymmetric (differential) ion mobility spectrometry (FAIMS/DMS) relationships between separation voltage (SV), compensation voltage (CoV) and the monoglycosphingolipid structural features of sugar headgroup, N-acyl chain length, and N-acyl degree of unsaturation. iDMS predicts the SV and CoV combinations capable of resolving any monoglycoceramide stereoisomer pair and can be trained using a dataset composed of empirically determined signal intensities for 12 or more stereoisomers (6 or more pairs of epimers) measured across a range of SVs and CoVs. It is recommended to acquire the training dataset using a CoV ramp step of 0.2 V.
iDMS is available as Python scripts, two Jupyter notebooks on Github, and here as a desktop application for Mac OS (Apple Silicon).
Nguyen-Tran T*†, Shi XX†, Hashimoto-Roth E, Organ MG, Lavallee-Adam M, Perkins TJ, Bennett SAL* (2026), Intelligent differential ion mobility spectrometry (iDMS): A deep neural network that predicts optimal space-resolved ion mobility parameters for isomeric monoglycosphingolipids. bioRxiv:2026.2008.2026.747394.
† Joint first authors
* Joint corresponding authors
Nguyen-Tran T†, Hashimoto-Roth E†, Shi XX, Organ MG, Lavallée-Adam M, Perkins TJ, and Bennett SAL. (2026) Desktop iDMS: A stand-alone desktop version of the iDMS neural network that predicts optimal separation and compensation voltages for field asymmetric differential ion mobility spectrometry (FAIMS/DMS).
† Joint first authors
iDMS is free software. You can redistribute it and/or modify it under the terms of the GNU General Public License v3 (or later versions) as published by the Free Software Foundation. As per the GNU General Public License, iDMS is distributed as a bioinformatic lipidomic tool to assist users WITHOUT ANY WARRANTY and without any implied warranty of MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE. All limitations of warranty are indicated in the GNU General Public License.